Apigenin: Uses, Benefits, Dosage & Safety
Last updated: June 2026 · Reviewed by the FactoWiki Editorial Team for clarity and source accuracy
Quick summary
Apigenin is the calming flavonoid in chamomile, studied for sleep, anxiety and as a mild antioxidant. It binds the same brain receptors as some sedatives, but human evidence is mostly indirect (via chamomile).
What is Apigenin?
Apigenin is a flavonoid found in chamomile, parsley and celery, and it's the compound widely credited for chamomile tea's calming effect. It's sold as a standalone supplement for sleep, relaxation and general antioxidant support.
What Apigenin is commonly used for
In supplements, Apigenin is most often included for brain & memory support. It is used as nutritional support, not as a treatment for any medical condition — the distinction matters, because the claims on a sales page are often stronger than the evidence allows.
How Apigenin works
Apigenin binds to benzodiazepine sites on GABA receptors in the brain — the same system targeted by some anti-anxiety and sleep medications — producing mild calming effects. It also has antioxidant and anti-inflammatory activity in lab studies.
What the evidence says
Here's an honest snapshot of what published research suggests about Apigenin — including where the evidence is limited.
- Chamomile (rich in apigenin) has modest human evidence for sleep and anxiety, supporting apigenin's calming reputation indirectly. (PubMed research)
- Direct human trials of isolated apigenin are limited, so its standalone effects are not well quantified. (PubMed research)
Typical dosage used in studies
No well-established isolated dose; chamomile studies use the tea or extract, and apigenin supplements vary. This is research information for context, not a recommendation — confirm what's appropriate for you with a healthcare professional.
Side effects and safety
Generally regarded as safe as a dietary flavonoid; it can cause mild drowsiness, in line with its calming action.
Medication interactions and who should avoid Apigenin
Medication & safety check
It may add to sedatives and affect drug-metabolising enzymes and blood thinners; caution with related medications.
This is general information, not personal medical advice. If you take any medication, confirm it's safe to combine with Apigenin with your doctor or pharmacist first.
Sources & further reading
The summary above is drawn from peer-reviewed research and authoritative references. For general, authoritative background you can also consult:
- PubMed research on Apigenin
- NIH Office of Dietary Supplements
- NIH National Center for Complementary and Integrative Health
- MedlinePlus (U.S. National Library of Medicine)
Frequently asked questions
Is apigenin what makes chamomile calming?
Yes — it's the flavonoid widely credited for chamomile's relaxing effect.
Does apigenin help sleep?
Chamomile has modest sleep evidence; direct isolated-apigenin trials are limited.
How does it work?
It binds GABA receptor sites in the brain, similar to some calming medications.
Is apigenin safe?
As a dietary flavonoid, generally yes; it can cause mild drowsiness.
Related ingredients to explore
Ingredients often studied or formulated alongside Apigenin — useful for understanding the full picture of a formula.