Benfotiamine: How It Works, Evidence & Safety

Last updated: June 2026 · Reviewed by the FactoWiki Editorial Team

Benfotiamine is a fat-soluble form of vitamin B1 (thiamine) with better absorption than regular B1, studied for nerve support. It is a core ingredient in formulas like Nervora.

What is Benfotiamine?

Benfotiamine is a synthetic, fat-soluble derivative of thiamine (vitamin B1). Because it absorbs better than standard thiamine, it can raise B1 levels in tissues more effectively.

How Benfotiamine works

It supports the thiamine-dependent enzymes nerves use for energy and helps blunt some of the glucose-driven chemical pathways that stress nerves over time.

What the evidence says

• A randomised, placebo-controlled study (BENDIP) reported improvement in neuropathy scores with benfotiamine. (PubMed)
• Reviews of thiamine and its derivatives discuss their role in nerve and metabolic health. (NIH Office of Dietary Supplements)

How much do studies use?

Studies have used roughly 300-600 mg per day. This is research information, not a personal recommendation.

Safety and side effects

Considered well tolerated in studies, with few reported side effects.

Who should avoid Benfotiamine?

As with any supplement, people who are pregnant, nursing, or on medication should check with a healthcare professional first.

Frequently asked questions

Is benfotiamine better than regular vitamin B1?

It is fat-soluble and absorbs better than standard thiamine, which is why it is often chosen for nerve-support formulas.

What is benfotiamine used for?

Mainly for nerve-health support and to help maintain healthy B1 status. It is nutritional support, not a treatment.