Licorice Root & DGL: Uses, Benefits, Dosage & Safety

Last updated: June 2026 · Reviewed by the FactoWiki Editorial Team for clarity and source accuracy

What is Licorice Root (DGL)?

Licorice (Glycyrrhiza glabra) root is used in both Eastern and Western herbal traditions for digestion, coughs and inflammation. Its sweet compound, glycyrrhizin, is responsible for both effects and risks. A processed form, DGL (deglycyrrhizinated licorice), removes most glycyrrhizin to make it safer for regular use.

What Licorice Root (DGL) is commonly used for

In supplements, Licorice Root (DGL) is most often included for gut & digestive health support. It is used as nutritional support, not as a treatment for any medical condition — the distinction matters, because the claims on a sales page are often stronger than the evidence allows.

How Licorice Root (DGL) works

Licorice has soothing, anti-inflammatory and demulcent effects on the gut and throat, and may support the stomach's protective mucus lining. The risk comes from glycyrrhizin, which causes the body to retain sodium and lose potassium, raising blood pressure — which DGL largely avoids.

What the evidence says

Here's an honest snapshot of what published research suggests about Licorice Root (DGL) — including where the evidence is limited.

• DGL has some supportive evidence for indigestion and ulcer symptoms, and licorice is a recognised traditional remedy for sore throat and gut irritation. (PubMed research)
• Whole-licorice safety concerns are well documented, which is why DGL is preferred for ongoing use. (PubMed research)

Typical dosage used in studies

DGL is often used as chewable tablets before meals; whole licorice should be limited due to glycyrrhizin. This is research information for context, not a recommendation — confirm what's appropriate for you with a healthcare professional.

Side effects and safety

DGL is generally safe. Whole licorice (and glycyrrhizin) can raise blood pressure, lower potassium and cause fluid retention, especially with regular or high intake.

Medication interactions and who should avoid Licorice Root (DGL)

Sources & further reading

The summary above is drawn from peer-reviewed research and authoritative references. For general, authoritative background you can also consult:

• PubMed research on Licorice Root (DGL)
• NIH Office of Dietary Supplements
• NIH National Center for Complementary and Integrative Health
• MedlinePlus (U.S. National Library of Medicine)

Frequently asked questions

What's the difference between licorice and DGL?

DGL has most of the glycyrrhizin removed, avoiding licorice's blood-pressure risk while keeping the soothing effect.

Is licorice bad for blood pressure?

Whole licorice (glycyrrhizin) can raise blood pressure and lower potassium — DGL largely avoids this.

Does DGL help heartburn or ulcers?

It has supportive evidence for indigestion and ulcer symptoms.

Who must avoid whole licorice?

People with high blood pressure, heart or kidney disease, and pregnant women.