Phosphatidylserine: How It Works, Evidence & Safety

Last updated: June 2026 · Reviewed by the FactoWiki Editorial Team

Phosphatidylserine is a phospholipid found in cell membranes, studied for memory support in older adults. It appears in several brain-health formulas.

What is Phosphatidylserine?

Phosphatidylserine is a fat (phospholipid) that is a major component of cell membranes, including in the brain. Supplements are usually derived from soy or sunflower.

How Phosphatidylserine works

It is part of the membranes brain cells use to communicate, and supplementing it is studied as a way to support memory and cognitive function, particularly with age.

What the evidence says

• Research has examined phosphatidylserine for age-related memory support, with some positive but limited findings. (PubMed research)

How much do studies use?

Studies have used around 100 mg, two to three times a day. This is research information, not a recommendation.

Safety and side effects

Generally well tolerated; mild stomach upset or insomnia are occasionally reported at higher doses.

Who should avoid Phosphatidylserine?

People on blood thinners or with medical conditions should check with a doctor, and soy-derived forms matter for those with soy allergy.

Frequently asked questions

What is phosphatidylserine good for?

It is studied mainly for memory and cognitive support in older adults, as nutritional support rather than a treatment.

Is it vegetarian?

Sunflower-derived phosphatidylserine is suitable for vegetarians; soy-derived is also plant-based. Check the label.