Andrographis: Uses, Benefits, Dosage & Safety

Last updated: June 2026 · Reviewed by the FactoWiki Editorial Team for clarity and source accuracy

What is Andrographis?

Andrographis (Andrographis paniculata) is a very bitter herb used in Ayurvedic and Chinese medicine, nicknamed 'king of bitters'. Its active compound is andrographolide, and it's used mainly for colds and upper-respiratory infections, often in standardised extracts.

What Andrographis is commonly used for

In supplements, Andrographis is most often included for respiratory & lung health support. It is used as nutritional support, not as a treatment for any medical condition — the distinction matters, because the claims on a sales page are often stronger than the evidence allows.

How Andrographis works

Andrographolide has immune-modulating and anti-inflammatory effects that may reduce the severity and duration of cold symptoms. It's thought to act on inflammatory signalling and immune responses rather than killing viruses directly.

What the evidence says

Here's an honest snapshot of what published research suggests about Andrographis — including where the evidence is limited.

• Several trials and reviews suggest andrographis (often standardised to andrographolide) can reduce the severity and duration of common cold and upper-respiratory symptoms — relatively good evidence for a botanical. (PubMed research)
• Most studies are short-term for acute illness rather than long-term use. (PubMed research)

Typical dosage used in studies

Cold studies have used extracts standardised to andrographolide, commonly providing tens of milligrams of andrographolide per day during illness. This is research information for context, not a recommendation — confirm what's appropriate for you with a healthcare professional.

Side effects and safety

Generally well tolerated short term; possible bitter taste, digestive upset, headache or, rarely, allergic reactions.

Medication interactions and who should avoid Andrographis

Sources & further reading

The summary above is drawn from peer-reviewed research and authoritative references. For general, authoritative background you can also consult:

• PubMed research on Andrographis
• NIH Office of Dietary Supplements
• NIH National Center for Complementary and Integrative Health
• MedlinePlus (U.S. National Library of Medicine)

Frequently asked questions

Does andrographis help colds?

Yes — it has relatively good botanical evidence for reducing cold severity and duration.

How does it work?

Mainly by modulating the immune and inflammatory response, not by killing viruses directly.

Is andrographis safe?

Short-term use is generally well tolerated; it's very bitter and can upset the stomach.

Who should avoid it?

Pregnant women, people on immunosuppressants or blood thinners, and those with autoimmune conditions (without advice).